Diastolic dysfunction and mortality in early severe sepsis and septic shock: a prospective, observational echocardiography study
1 Division of Pulmonary and Critical Care Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA
2 Division of Pulmonary and Critical Care Medicine, Intermountain Medical Center, Murray, UT, 84107, USA
3 Critical Care Echocardiography Service, Intermountain Medical Center, Murray, UT, 84107, USA
4 Division of Critical Care, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA
5 Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA, 91101, USA
6 Homer Warner Center for Informatics Research, Intermountain Healthcare, Salt Lake City, UT, 84107, USA
7 Division of Cardiology, Georgia Health Sciences Health System, Augusta, GA, 30912, USA
Critical Ultrasound Journal 2012, 4:8 doi:10.1186/2036-7902-4-8Published: 4 May 2012
Patients with severe sepsis or septic shock often exhibit significant cardiovascular dysfunction. We sought to determine whether severity of diastolic dysfunction assessed by transthoracic echocardiography (TTE) predicts 28-day mortality.
In this prospective, observational study conducted in two intensive care units at a tertiary care hospital, 78 patients (age 53.2 ± 17.1 years; 51% females; mean APACHE II score 23.3 ± 7.4) with severe sepsis or septic shock underwent TTE within 6 h of ICU admission, after 18 to 32 h, and after resolution of shock. Left ventricular (LV) diastolic dysfunction was defined according to modified American Society of Echocardiography 2009 guidelines using E, A, and e’ velocities; E/A and E/e’; and E deceleration time. Systolic dysfunction was defined as an ejection fraction < 45%.
Twenty-seven patients (36.5%) had diastolic dysfunction on initial echocardiogram, while 47 patients (61.8%) had diastolic dysfunction on at least one echocardiogram. Total mortality was 16.5%. The highest mortality (37.5%) was observed among patients with grade I diastolic dysfunction, an effect that persisted after controlling for age and APACHE II score. At time of initial TTE, central venous pressure (CVP) (11+/- 5 mmHg) did not differ among grades I-III, although patients with grade I received less intravenous fluid.
LV diastolic dysfunction is common in septic patients. Grade I diastolic dysfunction, but not grades II and III, was associated with increased mortality. This finding may reflect inadequate fluid resuscitation in early sepsis despite an elevated CVP, suggesting a possible role for TTE in sepsis resuscitation.